Evidence for functional endothelial cell damage in early diabetic retinopathy
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چکیده
منابع مشابه
Preoperative photocoagulation reduces corneal endothelial cell damage after vitrectomy in patients with proliferative diabetic retinopathy
Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes and is a leading cause of visual decline and irreversible blindness. So we designed this study to investigate retrospectively the effect of preoperative photocoagulation on corneal endothelial cells after vitrectomy in patients with PDR.The study included 52 eyes of 46 patients with PDR complicated with vitreous hemor...
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Diabetic retinopathy (DR) is a leading cause of visual impairment worldwide. Patients with DR may irreversibly lose sight as a result of the development of diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR); retinal blood vessel dysfunction and degeneration plays an essential role in their pathogenesis. Although new treatments have been recently introduced for DME, inc...
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The ultrastructure of old neovascular preretinal membranes was examined in both eyes of a patient with proliferative diabetic retinopathy treated in one eye with photocoagulation. Membranes in both eyes consisted of a matrix rich in mature collagen surrounding viable new vessels and "ghost vessels." Viable vessels of different calibers frequently showed endothelial fenestrae bridged by diaphrag...
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Recent evidence suggests an important role for outer retinal cells in the pathogenesis of diabetic retinopathy (DR). Here we investigated the effect of the visual cycle inhibitor retinylamine (Ret-NH2) on the development of early DR lesions. Wild-type (WT) C57BL/6J mice (male, 2 months old when diabetes was induced) were made diabetic with streptozotocin, and some were given Ret-NH2 once per we...
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| June 2013 | 536 paradox. According to this hypothesis, it seems that during the short period, arteriogenesis is reduced in diabetes mellitus due to VEGF resistance, however, in long‐period, angiogenesis increases in spite of VEGF resistance the results of high and continuous stimulation of VEGF.[5] Increase in arteriogenesis is associated with collateral vessel formation, while, increase in a...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1981
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00257426